Full-length cDNA sequening of brain-expressed gene of a cynomolgus monkey, Macaca fasciculariswas reported in PLOS Biology, and appeared in January as an online version.
In this paper, full-length cDNA sequencing on the brain transcriptome of an Old World monkey (OWM) was carried out, and then conducted comparative analysis among human, OWM, chimpanzee, and mouse. Authors belongs to the reserach institute and/or university in Japan, Taiwan, and USA. Dr. Takashi Gojobori, director of Center for Information Biology and DNA Data Bank of Japan(CIB-DDBJ), is one of the authors.
Brains of higher primates have evolved rapidly, whereas brain-expressed genes are known to evolve slowly in mammals. In human, there are a lot of questions between the rate of evolution of brain-expressed genes and evolution of the brain itself. To clear this questions, comparative study of the variation of the DNA sequences of various species is necessary.
The data was submitted to DDBJ/EMBL/GenBank International Nucleotide Sequence Databases and was released under the Accession numbers AB170063 - AB174733. The sequence information is available via DDBJ anonymous FTP (whole data download) or getentry system.
- Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates
PLoS Biol. 2007 February; 5(2): e13.
(Published online 2006 December 26. doi: 10.1371/journal.pbio.0050013.)
- getting the data
anonymous FTP file name:
QF base Macaca fascicularis cDNA database
Institute of Molecular Biology, Academia Sinica, Taiwan
Department of Ecology and Evolution, University of Chicago, USA
Division of Biomedical Research Resources, National Institute of Biomedical Innovation, Japan
Division of Genetic Resources, National Institute of Infectious Diseases, Japan
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Japan
Department of Life Science, Chang Gung University, Taiwan
Division of Molecular and Genomic Medicine, National Health Research Institute, Taiwan