DDBJ Center has been closely collaborating with EBI; European
Bioinformatics Institute/ ENA; European
Nucleotide Archive in Europe and NCBI;
National Center for Biotechnology
Information in USA to construct INSD;
International Nucleotide Sequence Database through exchanging data and
information on internet and by regularly holding two meetings,IAC; the
International Advisory Committee and ICM; the International
The operations of DDBJ, ENA/EBI, NCBI and ICM subscribe to advice from IAC.
Collaboration framework to construct International Nucleotide Sequence Database
From the beginning, 1980s, DDBJ has been functioning as one of the international nucleotide sequence databases, including
EMBL-Bank/EBI in Europe and
in the USA as the two other members.
In 2005, DDBJ, EMBL-Bank and GenBank agreed to call their collaboration INSDC; International Nucleotide Sequence Database Collaboration; and to call the unified nucleotide sequence database INSD; International Nucleotide Sequence Database.The agreement was approved by IAC in May 2005.
In 2009, INSDC added a coraborative meeting to deal with mass sequence data produced by the “next” generation sequencers (Sequence Read Archive) and traces produced by traditional gel/capillary sequencers (Trace Archive). In 2010, databases at EBI were integrated to ENA; European Nucleotide Archive.
Members of INSDC
|Data type||DDBJ Center||EMBL-EBI||NCBI|
|Next generation reads||Sequence Read Archive||European Nucleotide Archive (ENA)||Sequence Read Archive|
|Sequence Read Archive||Trace Archive||Trace Archive|
IAC; International Advisory Committee
International Advisory Committee consists of nine members, each of 3 members selected from Europe, US, or Japan.The committee meeting to advice in fairness to maintenance and future plan of INSDC is held once a year.
ICM; International Collaborative Meeting
International Collaborative Meeting consists of working-level participants of INSDC and its fundamental principle is international collaboration. The meeting to discuss practical matters to maintain and update INSDC is held once a year.
Overview of International Nucleotide Sequence Databases Policies
This brief policy statement, prepared by the International Advisory Committee to the International Nucleotide Sequence Databases (INSD; DDBJ/EMBL/GenBank), describes the procedures followed by the INSD.
These policies are unanimously recommended by the INSD advisors.
- Individuals submitting data to the international sequence databases managed collaboratively by DDBJ, EMBL, and GenBank should be aware of the following:
- The INSD has a uniform policy of free and unrestricted access to all the data records their databases contain. Scientists worldwide can access these records to plan experiments or publish any analysis or critique.Appropriate credit is given by citing the original submission, following the practices of scientists utilizing published scientific literature.
The INSD will not attach statements to records that restrict access to the data, limit the use of the information in these records, or prohibit certain types of publications based on these records. Specifically, no use restrictions or licensing requirements will be included in any sequence data records, and no restrictions or licensing fees will be placed on the redistribution or use of the database by any party.
All database records submitted to the INSD will remain an entry accessible as part of the scientific record. Corrections of errors and update of the records by authors are welcome and erroneous records may be removed from the next database release, but all will remain permanently accessible by accession number.
Submitters are advised that the information displayed on the web sites maintained by the INSD is fully disclosed to the public. It is the responsibility of the submitters to ascertain that they have the right to submit the data.
Beyond limited editorial control and some internal integrity checks (for example, proper use of INSD formats and translation of coding regions specified in CDS entries are verified), the quality and accuracy of the record are the responsibility of the submitting author, not of the database. The databases will work with submitters and users of the database to achieve the best quality resource possible.
The INSD is an outstanding example of success in building an immensely valuable, widely used public resource through voluntary ooperation across the international scientific community. This success has been achieved following the guidelines and principles outlined above.
- Signed by:
- Soren Brunak, Technical University of Denmark
- Antoine Danchin, Institut Pasteur
- Masahira Hattori, Kitasato University
- Tara Matise, Rutgers University
- Haruki Nakamura, Osaka University
- Daphne Preuss, University of Chicago
- Kazuo Shinozaki, RIKEN