Barcoded data files should be demultiplexed prior to submission and a unique BioSample should be created for each barcoded sample; in other words, each BioSample must be linked to one or more unique data files.
If necessary, describe relationship between barcode sequences and samples in the Library Construction Protocol of Experiment as free-text.

Regarding 10x Genomics data in which samples tend to be large number, please see the GEA Single-cell submission guide.

For details, see Data Files.